Expression of TBC1D24 appears ubiquitous, with the exception of spleen, and is predominant in the developing brain, in chondrocytes from the distal phalanges, and in the scull [2, 3], thus explaining why TBC1D24 mutations can induce epilepsies, mental retardation, onychodystrophies and osteodystrophies, as reported in the DOORS syndrome (OMIM #220500), or infantile myoclonic epilepsies (OMIM #605021) and epileptic encephalopathies (OMIM #615338). This evidence concerns the gene TBC1D24 and Epileptic encephalopathy.