In this study, we found the following: 1) the acetone extract of P. coriacea and its subcomponent, physciosporin, inhibit motility of lung cancer cells; 2) the extract of P. coriacea and physciosporin suppress EMT; 3) the extract of P. coriacea and physciosporin decrease KITENIN-mediated AP-1 activity and affect the expression of KAI1 and KITENIN; and 4) the extract of P. coriacea and physciosporin reduce RhoGTPase activity. Here, VANGL1 is linked to lung carcinoma.