Beyond TAA development, AT1aR-mediated, βarr2-dependent signaling in MFS has also been shown to contribute to the development of a primary dilated cardiomyopathy in a murine model of MFS (10), providing further corroborative evidence for a deleterious role of AT1aR-mediated, βarr2-dependent signaling in MFS. Here, AGTR1 is linked to Marfan syndrome.