IL6R and colonic neoplasm: Here, it should be noted that sIL-6R seems to have a beneficial role only in the nervous system—other studies suggest that IL-6 trans-signaling via the soluble IL-6R is pro-inflammatory in models of inflammatory bowel disease (IBD), peritonitis, rheumatoid arthritis, atherosclerosis pancreatitis, colon cancer, ovarian cancer and pancreatic cancer, and therefore soluble gp130Fc (gp130 fused with Fc, a constant region of an immunoglobulin heavy chain) is considered a possible therapeutic agent for the treatment of chronic inflammatory diseases and cancer [114].