IL6R and amyotrophic lateral sclerosis: In wobbler mice, an animal model showing close similarities to ALS [121], coadministration of IL-6 and sIL-6R delays the progression of motor neuron disease [122]; therefore, neurons appear to be sensitive to IL-6 signaling, even though they do not express IL-6R and IL-6 [120,123], and IL-6 signaling in neurons might function through the expression of gp130, a cytokine receptor that interacts with and is activated by the IL-6/sIL-6R complex.