For this purpose, we performed a literature search in the main medical databases (PubMed, Scopus, EMBASE and ScienceDirect), by using the following key words: celiac disease, atypical, latent, potential, seronegative, tissue transglutaminase, immunoglobulin deficiency, IgA deficiency, IgM deficiency, common variable immunodeficiency. This evidence concerns the gene TGM2 and selective IgA deficiency disease.