When they established the PASK-/- model, they found that PASK-/- mice fed a high-fat diet could be successfully protected from obesity owing to increased mitochondrial respiration accompanied with alteration on expression of a series of proteins or receptors [39] involved in lipid metabolism (Table 2), which might provide evidence for researching the new treatments of the metabolic diseases caused by lipid metabolic disorders. The gene discussed is PASK; the disease is obesity due to melanocortin 4 receptor deficiency.