When they established the PASK-/- model, they found that PASK-/- mice fed a high-fat diet could be successfully protected from obesity owing to increased mitochondrial respiration accompanied with alteration on expression of a series of proteins or receptors [39] involved in lipid metabolism (Table 2), which might provide evidence for researching the new treatments of the metabolic diseases caused by lipid metabolic disorders. This evidence concerns the gene PASK and metabolic disease.