Pathogenic variants in genes encoding enzymes involved in keratinocyte lipid processing, including ABCA12, ALOX12B, ALOXE3, CERS3, CYP4F22, NIPAL4, PNPLA1, and TGM1 [7], have been detected in patients with ARCI. This evidence concerns the gene ALOXE3 and autosomal recessive congenital ichthyosis.