We found no association between SNPs in the ESR1 gene with MetS, and only found significant association between women carrying the AA genotype of rs1884051 with elevated glucose levels (≥110 mg/dL) or previous diagnosis of T2D compared to the carriers of the GG genotype (OR = 2.9; 95% CI: 1.2–6.6; p = 0.013) (Table 3). Here, ESR1 is linked to type 2 diabetes mellitus.