Activation of SIRT3 via RSV in a murine model of cardiac fibrosis attenuated collagen deposition and cardiac hypertrophy via regulation of the TGF-β/Smad pathway; SIRT3 is required for the cardio-protective effects revealing a potential link between mitigation of oxidative stress and the signaling pathways responsible for fibrosis [142]. The gene discussed is SIRT3; the disease is cardiac hypertrophy.