Notably, a recent study using glioma and renal epithelial tumor cells showed that mitochondrial OGG1 is a direct SIRT3 deacetylation target and that SIRT3 deficiency reduces the oxygen consumption rate (OCR) and 8OHdG mtDNA BER that increases mtDNA damage and intrinsic apoptosis [126]. Here, SIRT3 is linked to central nervous system cancer.