NFE2L2 and pulmonary fibrosis: Persistent lung fibrosis in the aged mice was characterized by the accumulation of senescent and apoptosis-resistant myofibroblasts, as well as sustained alterations in redox balance resulting from the elevated expression of NOX4 and an impaired capacity to induce the nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated antioxidant response.