We also reported that oxidative stress (asbestos or H2O2) preferentially induces mtDNA than nuclear DNA damage in AEC both in vitro as well as in vivo and that OGG1 preservation of ACO-2 is crucial for preventing asbestos-induced AEC mtDNA damage, intrinsic apoptosis, and pulmonary fibrosis [8,98]. This evidence concerns the gene OGG1 and pulmonary fibrosis.