Sirt3-deficient (Sirt3−/−)mice have no obvious phenotype but are susceptible to age-linked diseases including metabolic syndrome, cancer, cardiac hypertrophy-fibrosis/CHF, hearing loss, acute renal injury, neurodegeneration, and radiation-induced fibrosis [124,137,138,139,140,141,142,143]. The gene discussed is SIRT3; the disease is cancer.