IFNA1 and systemic lupus erythematosus: Indeed, the identification of high levels of type I IFNs, and in particular of IFN-α, and the observation of a set of inflammatory genes induced by IFNs in biologic samples from patients with SLE (interferon signature), have demonstrated a common pathogenic pathway that underlies the heterogeneous spectrum of the disease and can also explain the onset of lupus-like syndromes or other condition with anti-dsDNA negative sera [82,83,84,85].