CIB1 and non-small cell lung carcinoma: Furthermore, in non-small cell lung cancer (NSCLC) and epithelial cell lines, β-elemene significantly arrested the cell cycle at the G2-M phase by decreasing the expression of Cyclin B1 and phospho-Cdc2 (Thr-161) and by increasing the expression of P27 (kip) and phospho-Cdc (Tyr-15) [11].