Whilst using non-invasive biomarkers is more appropriate in determining the presence of gut inflammation, it is impossible to correlate faecal S100A12 with certain histological subtypes of IBD (lymophocytic-plasmacytic enteritis, eosinophilic enteritis, etc.), since the specific type causing an increase and to what degree remain unknown. This evidence concerns the gene S100A12 and inflammatory bowel disease.