IDH1 and central nervous system cancer: Similarly, IDH1 (isocitrate dehydrogenase 1) mutations have been a powerful molecular marker to predict the prognosis of glioma subjects, where subjects with IDH1 mutations referred to as positive for IDH1 mutations (IDH1p) are known to have better prognosis than those with the wild type copy of the IDH1 gene (WT)7.