TP53 and head and neck squamous cell carcinoma: While introduction of MYH9 shRNA into murine embryos in a TGFβ-R-II deficient background promoted tumorigenesis and was linked to a defect in function of wild-type TP535, mutation of MYH9 and other NMHC II genes in human HNSCC is invariably linked to TP53 mutation in HPV- or inactivation in HPV+ human tumors.