The recently published Cancer Genome Atlas dataset16 for 279 HNSCC was analyzed for genomic alterations in NMHC II genes MYH9, 10 and 14, and for co-occurrence with human papilloma virus (HPV) status, selected mutations, and copy number alterations that are significant in HNSCC, as summarized by the Oncoprint in Fig. 917, 18. This evidence concerns the gene MYH9 and head and neck squamous cell carcinoma.