Moreover, Tiam1 expression affects the migration and invasion of many neoplasms, and high Tiam1 expression has indicated a poor prognosis in various tumors such as nasopharyngeal carcinoma [21, 22], primary gallbladder carcinoma [23], hepatocellular carcinoma [24, 25], papillary thyroid carcinoma [26], esophageal squamous cell carcinoma [27], retinoblastoma [28], and prostate carcinomas [29]. This evidence concerns the gene TIAM1 and retinoblastoma.