The first group (ES 21) contains PRELID1 (mitochondrial morphology and function) [13], CHCHD2 (regulator of cytochrome oxidase) [14], ISOC2 (tumor development) [15], and MRPL53 (a mitochondrial ribosomal protein also found in [16] in a putative ribonucleotide complex with LRPPRC and SLIRP). The gene discussed is PRELID1; the disease is neoplasm.