IDH1 and central nervous system cancer: Histological grade showed a good prognostic breakdown in IDH1/2 mutated gliomas (p < 0.0001), IDH1/2 wild-type gliomas (p < 0.0001), 1p/19q codeleted gliomas (p = 0.024), 1p/19q non-deleted gliomas (p < 0.0001), TERTp mutated gliomas (p < 0.0001) and TERTp wild-type gliomas (p < 0.0001), indicating that prognostic value of histological grade was independent of these three molecular markers.