While IDH1/2 mutation showed a wide prognostic split across the whole cohort (Fig. 1d), the lack of prognostic difference between IDHmut gliomas and IDHwt gliomas could be partially due to the elimination of the favorable prognostic effect of IDHmut-OT gliomas from the IDH1/2 mutated tumors as well as the unfavorable prognostic effect of IDHwt-ET gliomas from the IDH1/2 wild-type tumors, therefore bringing the two survival curves overlapping with each other (Fig. 4a). This evidence concerns the gene IDH1 and central nervous system cancer.