On the other hand, Wnt3a antagonizes the inhibition of the self-renewal of liver cancer stem cells induced by 8-bromo-7-methoxychry [55], promotes the self-renewal of leukemic stem/progenitor cells in some acute myeloid leukemia and acute T-lymphoblastic leukemia cell lines [25], promotes the proliferation and survival of acute lymphoblastic leukemia cells [56], reduces the anti-proliferative activity of lenalidomide multiple myeloma [57], and stimulates the proliferation of malignant mesothelioma cells [58]. The gene discussed is WNT3A; the disease is plasma cell myeloma.