The mitogen activated and extracellular regulated kinase (MEK) inhibitor PD98059, genistein, and wortmannin effectively suppress Wnt3a/β-catenin–regulated transcriptional activities as well as the intracellular accumulation of β-catenin protein in human colon cancer cells [100]. The gene discussed is WNT3A; the disease is malignant colon neoplasm.