WNT3A and malignant mesothelioma: Furthermore, Wnt3a treatment significantly decreases the drug susceptibility of cholangiocarcinoma QBC939 cells to common chemotherapeutics [65], sensitizes malignant mesothelioma cells to cytotoxic drugs [58], and induces striking morphological changes accompanied by the rearrangement of the actin cytoskeleton in myeloma cells [66].