It has been reported that based on the expression of Wnt3a, erb-b2 receptor tyrosine kinase 3 (ERBB3), lymphocyte-specific protein tyrosine kinase (LCK), and Rho family GTPase 3 (RND3) to predict mortality, the four-gene model achieved better predictive value than clinical stage or tumor size in early-stage non–small cell lung cancer [67]. This evidence concerns the gene RND3 and neoplasm.