SENP2 and breast cancer: However, neither the band density in the nuclear fraction, nor the band density in the cytosolic fraction, was altered in T24-SENP2 cells with β-catenin antibody after WNT5a treatment, suggesting SENP2 may inhibit SUMOylation of some proteins that are required for nuclear translocation of β-catenin by WNT5a in BC cells (Fig. 2).