In addition, TRAIP interacts with CYLD [11] and Syk [5], two tumor suppressors implicated in the formation of skin appendages tumors such as cylindroma, trichoepithelioma and spiradenoma (CYLD) [12, 13] and of melanomas and breast tumors (CYLD and Syk) [14-18]. The gene discussed is TRAIP; the disease is neoplasm.