It has emerged as a strong prognostic biomarker in patients with HF and myocardial infarction, and just recently, increased sST2 in patients with stable CHD in the LURIC study has been shown to be an independent predictor of long-term all-cause mortality and to provide complementary prognostic information to hsTnT and NT-proBNP [25]. The gene discussed is NPPB; the disease is hydrops fetalis.