Notably, IDH mutations have also been found in numerous cartilaginous neoplasms, including 71% of conventional chondrosarcomas and 57% of dedifferentiated chondrosarcomas, as well as enchondromas, sporadic central cartilaginous tumors, and periosteal chondromas [1, 3, 13, 14]. This evidence concerns the gene IDH2 and chondrogenic neoplasm.