ICAM1 and sarcoidosis: This difference may have been because our study had fewer cases than the study by Hamzaoui et al. In terms of the mechanism and relevance of the high expression of ICAM-1 in sarcoidosis patients, current research has demonstrated that alveolar macrophages associated with the sarcoidosis granulation tissue could synthesize and release 1,25-dihydroxycholecalciferol, leading to hypercalcinemia.