As shown in Fig 4A, the fixed effect meta-analysis of the 7 studies indicated a positive relationship between MUC1 expression and CRC Duke’s stage with the pooled OR of 3.02 and 95% CI of 2.11–4.33 (χ2 = 9.18, P = 0.164, I2 = 34.7%). The gene discussed is MUC1; the disease is colorectal carcinoma.