Furthermore, in a study with S2-013.MUC1F pancreatic cancer cells, MUC1 expression conferred on tumors a greater propensity to metastasize when present in low hepatocyte growth factor (HGF) tissue environments but conversely downregulated HGF-stimulated activation of motility and invasion under conditions of high HGF concentrations [64]. This evidence concerns the gene HGF and familial pancreatic carcinoma.