In CRC patients with metastasis, the average positive rate was 44.6% (range from 20.0% to 62.7%) in the 6 studies using Ma695, 63.5% (range from 49.5% to 92.7%) in the 3 studies using KL-6 and 40.6% (range from 32.5% to 50.2%) in the 2 studies using HMFG-2. The gene discussed is MUC1; the disease is colorectal carcinoma.