The result suggested a positive correlation or tendency of MUC1 expression with node metastasis of MMR-proficient CRC (OR = 1.06, 95% CI = 0.82–1.34), MLH1-negative CRC (OR = 1.02, 95% CI = 0.44–2.33) and presumed hereditary non-polyposis colon cancer (HNPCC) (OR = 0.81, 95% CI = 0.23–2.82), which was almost consistent with the impact of MUC1 expression on the node metastasis of overall CRC (OR = 1.00, 95% CI = 0.79–1.27) in the study. The gene discussed is MLH1; the disease is hereditary nonpolyposis colon cancer.