The gene HCG27 (HLA complex group 27) is a non-protein coding gene; though HLA genes have been consistently been associated with AIDS progression [2,50], the role of this gene (as well as that of other candidate genes revealed in this study, such as SLC35B4, GUCA1B) is difficult to evaluate to the best of our knowledge. The gene discussed is GUCA1B; the disease is AIDS.