ITIH4 and HIV infectious disease: The association of low expression of chaperone-coding gene CCT8 with slow- and non-progression also points to a role of chaperones in promoting HIV infection; also of interest is the observation that CCT8 is one of the proteins to be differentially regulated in synaptosomal isolates from HIV/gp120 transgenic mice [46]; an association between CCT8’s expression and rs2205418 is also reported in the Geuvadis database (p = 1.7×10−8) [23].