No significant difference in adiponectin in OSA patients was observed before and after CPAP treatment after pooling the data with meta-analysis (SMD = 0.059, 95% confidence interval (CI) = −0.250 to 0.368, z = 0.37, p = 0.710) (Fig 2). The gene discussed is ADIPOQ; the disease is obstructive sleep apnea syndrome.