CD4 and Autoimmunity: This Th1 response is independent of IL-1R and IL-18R, implying a role for TLRs in orchestrating MyD88-mediated T cell responses to T. gondii. Toll-like Receptor 2 signaling in CD4+ T cells is known to promote Th17 responses in vitro [29] and regulate the pathogenesis of autoimmunity in a model of experimental autoimmune encephalitis (EAE).