ICAM1 and early-onset autosomal dominant Alzheimer disease: These mediators include nitricoxide (NO), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and intercellular adhesion molecule-1 (ICAM-1)[5–7], which have been implicated in brain diseases such as trauma, seizures, ischemia and Alzheimer’s disease [4].