As shown in Fig H of the S1 File, human skeletal muscle resistance artery myogenic tone did not differ when segregated by (i) serum NT-proBNP levels (positive versus negative result) [18]; (ii) New York Heart Association (NYHA) functional class (Class I versus Classes 2 and above) [24,25]; (iii) the presence of reduced left ventricular ejection fraction (normal defined as ≥55%) [25]; or (iv) previous history of myocardial infarction. Here, NPPB is linked to myocardial infarction.