The expression of biliary glycoprotein-1 (Bgp1), the receptor for MHV-3 [19], appeared to be significantly lower in the virus infected IL-1R1-/- livers comparing to that in the WT controls (Fig 2C), concurring with the plaque assay data showing with limited virus entrance and amplification in the livers 72h post-infection (Fig 2D). Here, CEACAM1 is linked to infection.