Conversely, it is worth mentioning that not all p47phox-/- mice are completely resistant to MHV-3, and these animals eventually still died from the infections (Fig 8B), together with some virus infected mice still produce high levels of IL-1β and virus titers, suggesting the presence of other mediators that in response to the virus challenge, are capable of activating NLRP3 inflammasome in vivo. This evidence concerns the gene NLRP3 and infection.