NLRP3 inflammasome and IL-1β mediate the host protection against pathogen invasions, whereas, the hyperactivation of NLRP3 inflammasome contributes to the pathogenesis of certain inflammatory syndromes, including liver injuries such as nonalcoholic/alcoholic steatohepatitis [8, 9], liver fibrosis [10], and immune mediated liver injuries [11]. The gene discussed is NLRP3; the disease is Hepatic fibrosis.