When the INDELs were analyzed by logistic regression, NFKβ1 showed significant differences like risk factor associated with the presence of the allele DEL in MB patients (p = 0.024; OR[IC95%] = 2.64[1.13–6.19]), of contradictory way the dominance effect of DEL allele seem protect against the development of leprosy, but when the disease is established your effect seem inefficient to combat to bacilli. This evidence concerns the gene NFKB1 and leprosy.