The current study select eight INDEL in seven genes (CYP19A1, NFKβ1, IL1α, CASP8, UGT1A1, PAR1, CYP2E1, and IL4), which have relation with the immune response modulation in leprosy patients, beside literature that demonstrate these molecular markers like functional polymorphisms that alter transcriptional activity of the gene, and consequently the immunological phenotype against the bacilli. Here, CASP8 is linked to leprosy.