In particular, the group of Lars-Olaf Cardell have carried out a series of studies with nasal LPS challenge: measuring CCL3 (MIP1α) in nasal lavage [23], evaluating a CXCR2 antagonist [24], demonstrating that allergen primes LPS responses [25], and showing that LPS challenge has augmented nasal cytokine release in allergic rhinitis [26]. The gene discussed is CCL3; the disease is allergic rhinitis.