As shown in Fig 1, a significant upregulation of DKC1 (p = 0.025), RAD50 (p = 0.0001), MRE11 (p = 0.005), NBS1 (p = 0.032) and RPA1 (p = 0.012) expression in MM compared with MGUS was detected. This evidence concerns the gene RAD50 and Miyoshi myopathy.