Loss of vaccine-mediated protection during malaria parasite infection was independent of Slc11a1 (Nramp1) genotype and route of S. Typhimurium infection, as we observed the same effect in both C57BL/6 Slc11a1+/+ mice with i.v. infection routes and in CBA mice with intragastric (i.g.)routes (Figs 1D, S2C and S3). This evidence concerns the gene SLC11A1 and infection.