Although TIMP-1 is emerging as an important prognostic marker in clinical findings and several studies have documented the prognostic value of TIMP-1 in lung cancers [16, 33, 34], the antiapoptotic role of TIMP-1 has not been robustly addressed in lung adenocarcinoma cell lines, with the majority of studies having been carried out using the A549 cell line with conflicting results [35, 36]. This evidence concerns the gene TIMP1 and lung cancer.