In contrast to the healthy subjects and non-IGCS-treated patients with BA, the production of the proinflammatory cytokines IL-12, IFN-γ, IL-8, IL-6, and TNF-α by the macrophages from the IGCS-treated patients with BA decreased in response to RF-M1 and increased in response to RF-M2, whereas the production of the anti-inflammatory cytokines IL-4, IL-5, and IL-10 decreased in response to RF-M2 and increased in response to RF-M1. The gene discussed is IL4; the disease is breast angiosarcoma.