Consistent with our predictions, a higher genetic risk score significantly predicted a higher risk of having cognitive impairment (OR = 3.824, P = .013, and 95% C.I. = 1.333, 10.973) when controlling individual polymorphisms in BDNF, COMT, and APOE (see Tables 4 and 5). The gene discussed is BDNF; the disease is Cognitive impairment.