After removing the 4 individuals with dementia from the analysis, the risk score remained significant (OR = 3.138, P = .039, and 95% C.I. = 1.059, 9.302) while the individual genotypes remained nonsignificant in the full model, with the exception of COMT which reached nominal significance (BDNF, OR = .446, P = .248, and 95% C.I. = .113, 1.755; COMT, OR = 1.977, P = .095, and 95% C.I. = .889, 4.396; APOE, OR = .899, P = .105, and 95% C.I. = .790, 1.022). The gene discussed is BDNF; the disease is dementia.