Liu et al. reported that a reduction of 5hmC is associated with the downregulation of the TET1 protein in HCC [18] while Gao et al. claimed a downregulation of TET1 and TET2 but no change in TET3 gene expression with a concomitant decrease of 5hmC in HCC [26]. Here, TET3 is linked to hepatocellular carcinoma.