A 24-week treatment with acarbose led to significantly increased levels of both fasting and postprandial GLP-1 as well as significantly increased nitric oxide (NO) levels and nitric oxide synthase (NOS) activity for those patients in whom postprandial GLP-1 levels were increased in 24 newly diagnosed patients with T2DM [83]. This evidence concerns the gene GLP1R and type 2 diabetes mellitus.