Women with PCOS who were lean and had normal glucose tolerance were treated with ethinyl estradiol 30 μg/drospirenone 3 mg (EE/DRSP) for 3 months and had significantly reduced fasting and postprandial levels of GLP-1 and a decreased AUC for GLP-1 [25]. This evidence concerns the gene GCG and polycystic ovary syndrome.