However, a previous meta-analysis which did not include the JUPITER trial demonstrated a strong relationship between average changes in LDL-C and CRP (r = 0.80, P <0.001) in healthy subjects and subjects with stable coronary artery disease who were treated with LDL-lowering interventions in placebo-controlled trials [34], but this meta-analysis was performed using mean levels of LDL-C and CRP changes in each trial and this may not reflect the true correlation between the changes in LDL-C and CRP in individuals. The gene discussed is CRP; the disease is coronary artery disorder.