Similarly, LEPR 668 A/G + G/G carriers with a high fat total intake had 3.0 times higher risk of obesity (P = 0.002) and 4.1 times higher risk of cholesterol levels ≥200 mg/dL (P = 0.001) than those with a low intake of total fat <83 g/d. The gene discussed is LEPR; the disease is obesity due to melanocortin 4 receptor deficiency.