In this study we found a gene-diet interaction for the 668 A/G polymorphism in the LEPR gene and 56 C/G in the APOA5 gene with a high intake of saturated fatty acids (SFA) and total fat was associated with obesity, hypercholesterolemia and hypertriglyceridemia. The gene discussed is APOA5; the disease is obesity due to melanocortin 4 receptor deficiency.