This analysis revealed that A/G + G/G genotypes of the 668 A/G polymorphism in the LEPR gene with an intake ≥12 g/d of saturated fatty acids, have 2.9 times higher risk of obesity (P = 0.002), 3.8 times higher risk of cholesterol levels ≥200 mg/dL (P = 0.002) and 2.4 times higher risk of triglyceride levels ≥150 mg/dL (P = 0.02), than those with an intake <12 g/d of saturated fatty acids. The gene discussed is LEPR; the disease is obesity due to melanocortin 4 receptor deficiency.