MFN2 and neurodegenerative disease: In many types of neurodegenerative diseases, a significant reduction in the levels of fusion proteins optic atrophy-1 (Opa-1), mitofusin-1 (Mfn-1) and mitofusin-2 (Mfn-2) as well as the fission protein dynamin-related protein-1 (Drp-1) is reported, as well as an increase in the level of the fission related protein-1 (Fis-1) [5].