Patient 4 had the tumor biopsy (4T) and margins (4PM and 4DM) methylated for all, CDH1, CDKN2A, DAPK, and TIMP2, except for 4DM not being methylated for CDH1. The tumor tissue of patient 8 (8T) and the respective adjacent margin (8DM) were not methylated for CDH1 and CDKN2A; yet, DAPK and TIMP2 were both methylated for 8T and 8DM. The gene discussed is TIMP2; the disease is neoplasm.