As shown in Fig. 4d, the level of sialylated gp96 in SW1990 was 79 % of that in A549 and HeLa cells (P < 0.01), which suggested that the sialylation level of gp96 differs in different cancer cell lines and indicated that the sialylation level of gp96 or perhaps other glycoproteins may play an important role in tumorigenesis and development. This evidence concerns the gene HSP90B1 and cancer.