The FTO locus is not only strongly associated with T2D risk [50••] and higher BMI [52] but also increased fasting insulin and homeostatic model estimated insulin resistance (HOMA-IR; p = 9.5 × 10−5), which is in agreement with insulin resistance playing a part in the FTO association with T2D via increased BMI [52]. Here, INS is linked to type 2 diabetes mellitus.