The T2D risk allele of another IRS1 variant, rs2943640 (r2 = 0.97, D′ = 1.00, HapMap2, CEU), was also nominally associated with decreased BMI (beta = −0.014, p = 1.1 × 10−5; Fig. 2) [58••]. The gene discussed is IRS1; the disease is type 2 diabetes mellitus.