For instance, the ARL15 (rs702634) T2D risk allele was associated with increased fasting insulin (BMI-adjusted, p = 5 × 10–12), HOMA-IR (p = 0.02) and triglyceride levels (p = 0.01) as well as decreased high-density lipoprotein (HDL) levels and BMI (p = 5.6 × 10−5) [50••]. Here, INS is linked to type 2 diabetes mellitus.