INS and Insulin resistance: In addition, another SNP (rs571312) at the same locus, in strong linkage disequilibrium with rs12970134 (r2 = 0.87, D′ = 0.96, HapMap2, Utah Residents with European ancestry population (CEU)), was associated with increased fasting insulin (p = 5.2 × 10−5), HOMA-IR (p = 7.6 × 10−5) and T2D (p = 0.0004), which is in agreement with insulin resistance playing a part in the MC4R association with T2D through BMI [52].