For instance, while the T2D risk allele in GCKR is associated with increased BMI (rs780094, C allele, beta = 0.01, p = 0.0002) [58••] (Fig. 2), the same variant has an opposite effect on WHRadjBMI (rs780094, beta = −0.01, p = 0.004) [62••] (Fig. 3). The gene discussed is GCKR; the disease is type 2 diabetes mellitus.