ADCC is stimulated through the interaction between Fc fragment of lgG1 monoclonal antibodies linked with EGFR of targeted cancer cell and the surface Fc gamma receptor 2a and 3a (FCGR2A and FCGR3A) of IgG carried by immune cells such as natural killer lymphocytes (NK), macrophages and neutrophil, triggering the activation of these immune effective cells and leading to the lysis and death of targeted cancer cell. The gene discussed is FCGR3A; the disease is cancer.