SIRT1 and colorectal carcinoma: We also analyzed the prognostic value of the SIRT1 mRNA level on the basis of two independent cohort studies and observed a significant correlation between high SIRT1 expression and decreased disease-free survival (pooled GSE14333 and GSE17536 CRC data sets, P = 0.011; HR = 1.663, 95% CI of ratio = 1.123–2.457; n = 351).