In the current study, for the first time, we simultaneously compared the expression level of ANXA2 and HE4 in endometrial tissues by immunohistochemistry assays, analyzed the correlation of the two molecules and investigated the effects of them on the development of endometrial carcinoma, and the interaction between ANXA2 and HE4 in the progression of endometrial carcinoma. Here, WFDC2 is linked to endometrial carcinoma.