Clinical observations of IL-4 in allergic asthma include increased IL-4 in the serum and bronchoalveolar lavage (BAL) of allergic individuals [8, 9], while nebulized IL-4 given to patients with mild asthma results in a significant increase in AHR associated with the elevation of sputum eosinophil numbers [10]. The gene discussed is IL4; the disease is asthma.