The Th2 cytokines, including interleukin (IL)-4, IL-5, IL-9, IL-13 and IL-25, together promote key pathophysiological features of asthma including allergen-specific IgE, airway inflammation (characterized by activated lymphocytes, eosinophils, mast cells and macrophages), damage to the airway epithelium, mucus gland hyperplasia and structural remodelling of the airway wall [2–4]. This evidence concerns the gene IGHE and asthma.