IL13 and asthma: In mice, human IL-13 promotes many of the inflammatory changes associated with asthma, such as inflammatory cell infiltration in the lungs and AHR and goblet cell metaplasia [16, 17]; treatment with an anti- IL-13 monoclonal antibody (mAb) has been shown to be effective in mice [18], although poorer outcomes have been realised to date in human clinical trials [19, 20].