Unfortunately, our current understanding of the role of Th2cytokines in larger animal models of asthma, where experimental therapeutic and in real-time manipulation is viable, is limited to a description or phenotypic analysis of inflammatory cells involved in the allergic response (reviewed in [25, 26]), and a single study in non-human primates reporting elevated mRNA expression of IL-4 and IL-13 in HDM-challenged airways [27]. The gene discussed is IL4; the disease is asthma.