C-statistic showed that carotid artery plaque assessment best improved the prediction of obstructive CAD and the intention for revascularization while ABI was inferior and CIMT failed to give independent impact to a model including TRF and clinical factors (CF, including angina, NYHA, history of PVD, reduced left-ventricular ejection fraction <50 %, hsCRP, ntproBNP), Fig. 2. This evidence concerns the gene NPPB and coronary artery disorder.